IEEE International Symposium on Hardware Oriented Security and Trust (HOST) is the premier symposium that facilitates the rapid growth of hardware-based security research and development. Since 2008, HOST has served as the globally recognized event for researchers and practitioners to advance knowledge and technologies related to hardware security and assurance. Rapid proliferation of computing and communication systems with increasing computational power and connectivity into every sphere of modern life has brought security to the forefront of system design, test, and validation processes. The emergence of new application spaces for these systems in the internet-of-things (IoT) regime is creating new attack surfaces as well as new requirements for secure and trusted system operation. Additionally, the design, manufacturing and the distribution of microchip, PCB, as well as other electronic components are becoming more sophisticated and globally distributed with a number of potential security vulnerabilities. Therefore, hardware plays an increasingly important and integral role in system security with many emerging system and application vulnerabilities and defense mechanisms relating to hardware. IEEE International Symposium on Hardware Oriented Security and Trust (HOST) aims to facilitate the rapid growth of hardware-based security research and development. HOST highlights new results in the area of hardware and system security. Relevant research topics include techniques, tools, design/test methods, architectures, circuits, and applications of secure hardware. The IEEE International Symposium on Hardware Oriented Security and Trust (HOST) - the premier event aiming to facilitate the rapid growth of hardware security research and development - has opened its call for contributions. The 18th annual HOST will be held May 5-8, 2025 in San Jose, California, the capital of Silicon Valley. HOST 2025 invites original contributions in all areas of overlap between hardware and security, including but not limited to the following: Computer-aided Design (CAD) for Hardware Security Verification e.g., automatic techniques and metrics for life cycle security management and detecting security vulnerabilities. Hardware Security Primitives e.g., PUFs, TRNGs, cryptography, post-quantum cryptography, odometers. Hardware Attack and Defense e.g., hardware Trojans, fault injection, side-channels, hardware reverse engineering, hardware obfuscation. Architecture Security e.g., architectural side-channels, trusted execution environment, FPGA and reconfigurable fabric security. System security e.g., machine learning security, SoC/IP security, CPS/IoT security, sensor network security, smart grid security, cloud security. Emerging Security and Privacy Threats and Solutions e.g., privacy-enhancing architecture, blockchain, cryptocurrency security, and other hardware/system security topics. Paper Submission: HOST 2025 has two submission windows. Please submit your paper at https://easychair.org/conferences/?conf=host2025. The page limit for submitted papers is 10 pages (excluding references), in double column, IEEE format, with a minimum font size of 10 points. Paper templates are available at https://www.ieee.org/conferences/publishing/templates.html. Only work that has not been previously published at the time of the submission will be considered. Duplicate submissions to concurrent conferences/journals are not permissible, and if encountered will be rejected and reported to IEEE. The paper selection will involve a double-blind review - the identity of authors must not be revealed, directly or indirectly, over the course of the entire process, with all references to the author(s)' own previous work being in the third person. Please avoid the use of “omitted for blind review” in the bibliography and make sure that the PDF metadata does not contain author information. Conflict of Interest Declaration: Before the full paper submission deadline, please declare your conflicts of interest with the TPC members on EasyChair, using the “Declare conflict” link on the top right corner of your paper information page. Conflicts of interest for HOST 2025 include authors of the submission, family members, advisors/students, colleagues from the same institution, and co-authors/collaborators in the past 48 months. General Co-Chairs Waleed Khalil, The Ohio State University - khalil.18@osu.edu Mark Tehranipoor, University of Florida - tehranipoor@ece.ufl.edu Program Co-Chairs Naghmeh Karimi, University of Maryland, Baltimore County - naghmeh.karimi@umbc.edu Ujjwal Guin, Auburn University - ujjwal.guin@auburn.edu Vice-program Co-Chairs Prabhat Mishra, University of Florida - prabhat@ufl.edu Jeyavijayan Rajendran, Texas A&M University - jeyavijayan@tamu.edu Registration / Travel Chair Ioannis Savidis, Drexel University - isavidis@coe.drexel.edu Finance Chair Aydin Aysu, NC State University - aaysu@ncsu.edu Publicity / Website Chair Kyle Juretus, Villanova University - kjuretus@villanova.edu Publications / AV Chair Eslam Yahya Tawfik, The Ohio State University - tawfik.10@osu.edu Panel Chair Adam Kimura, Battelle - kimura@battelle.org Ph.D. Competition Co-Chairs Mengmei Ye, IBM Research - mye@ibm.com Xiaolin Xu, Northeastern University - x.xu@northeastern.edu Hardware Demo / Posters Chair Hadi Mardani Kamali, University of Central Florida - hadi.mardanikamali@ucf.edu Steering Committee: Mark Tehranipoor (Chair), University of Florida Jim Plusquellic, University of New Mexico Farinaz Koushanfar, University of California, San Diego Swarup Bhunia, University of Florida Ramesh Karri, Polytechnic Institute of New York University Yousef Iskander, Microsoft Saverio Fazzari, Booz Allen Hamilton Fareena Saqib, University of North Carolina, Charlotte Vincent Mooney, Georgia Institute of Technology Farimah Farahmandi, University of Florida Contact Inforamtion: Program Chairs Ujjwal Guin, Email:ujjwal.guin@auburn.edu Naghmeh Karimi, Email:nkarimi@umbc.edu General Chairs Waleed Khalil, Email:khalil.18@osu.edu Mark Tehranipoor, Email:tehranipoor@ece.ufl.edu